代表性成果 | 成果簡介 | ||||||
1.闡明孤獨(dú)癥關(guān)鍵致病因子的功能及致病機(jī)制 | 通過自主構(gòu)建孤獨(dú)癥關(guān)鍵致病因子的基因編輯動物模型，揭示了FOXG1、Neurexin/Neuroligin、ROCK/PAK/LIMK等致病因子或信號通路在大腦模式形成、神經(jīng)元命運(yùn)決定和發(fā)生、神經(jīng)元遷移和軸突投射、突觸形成和通常可塑性等過程中的作用，揭示了上述致病因子和信號通路異常導(dǎo)致孤獨(dú)癥的機(jī)制，對闡明兒童孤獨(dú)癥的發(fā)病機(jī)制及相應(yīng)診治具有重要意義。 | ||||||
2. 多基因協(xié)同促進(jìn)內(nèi)耳干細(xì)胞再生重建聽覺功能 | 研究了Wnt、FoxG1、Spectrin等基因在內(nèi)耳干細(xì)胞增殖分化、毛細(xì)胞成熟和存活中的作用機(jī)制；優(yōu)化了高效轉(zhuǎn)染內(nèi)耳干細(xì)胞的新型腺相關(guān)病毒, 建立了小鼠內(nèi)耳干細(xì)胞的基因治療系統(tǒng)。研究了多種生物材料和電、磁等物理刺激對聽覺神經(jīng)元再生、功能成熟和存活的調(diào)控機(jī)制。開創(chuàng)性地研究了自噬和免疫系統(tǒng)促進(jìn)毛細(xì)胞和神經(jīng)元存活的作用和機(jī)制。 | ||||||
3.揭示本能行為和學(xué)習(xí)記憶的分子與神經(jīng)環(huán)路機(jī)制 | 闡明了生物節(jié)律通過特異性節(jié)律輸出分子Fbxl4調(diào)控睡眠的分子細(xì)胞機(jī)制，揭示生物節(jié)律調(diào)控睡眠行為的作用機(jī)制。闡明機(jī)體在睡眠和求偶兩種本能行為間抉擇的機(jī)制，揭示了睡眠與求偶行為在神經(jīng)環(huán)路上的相互作用。發(fā)現(xiàn)PKCλ與PKMζ分別在學(xué)習(xí)記憶的早期表達(dá)、鞏固及后期維持階段的作用，揭示一種存在于胞體的調(diào)節(jié)突觸傳入的細(xì)胞新機(jī)制。 | ||||||
4.揭示干細(xì)胞命運(yùn)決定及重編程的轉(zhuǎn)錄調(diào)控機(jī)制 | 發(fā)現(xiàn)鋅指蛋白ZFP281募集AFF3到增強(qiáng)子上精確調(diào)控印記基因的差異性表達(dá)，以及協(xié)同甲基轉(zhuǎn)移酶MLL2調(diào)控轉(zhuǎn)座子LINE-1區(qū)的組蛋白修飾以及染色質(zhì)局部結(jié)構(gòu)，調(diào)控干細(xì)胞的命運(yùn)決定及重編程。揭示SEC介導(dǎo)多價相分離調(diào)控RNA聚合酶II轉(zhuǎn)錄暫停釋放，從全新角度闡明基因快速協(xié)調(diào)轉(zhuǎn)錄激活程序的機(jī)制，為探索SEC相關(guān)疾病的機(jī)制及篩選靶向藥物提供了新思路。 | ||||||
5. 原發(fā)性膽汁性膽管炎發(fā)病機(jī)制的研究 | 通過對漢族人群原發(fā)性膽汁性膽管炎（PBC）易感基因的研究，在國際上首次發(fā)現(xiàn)IL-21信號通路和T細(xì)胞輔助激活的異常在PBC發(fā)病機(jī)制中的重要作用，并通過CD58易感基因的發(fā)現(xiàn)把膽汁上皮細(xì)胞相關(guān)基因功能和PBC發(fā)病機(jī)制結(jié)合起來，為進(jìn)一步探討PBC發(fā)病機(jī)制提供了線索。 | ||||||
序號 | 論文題目 | 第一作者 | 通訊作者 | 刊物名稱 | 發(fā)表時間 | 代表性成果 | |
1 | Neuroligin 1 regulates spines and synaptic plasticity via LIMK1.cofilin-mediated actinreorganization | 劉安 | 謝維；加正平 | The Journal of Cell Biology | 201602 | 1 | |
2 | p21-activated kinase 1 restricts tonic endocannabinoid signaling in the hippocampus | 夏淑婷 | 謝維；加正平 | eLife | 201606 | 1 | |
3 | Mutations of PQBP1 in Renpenning syndrome promote ubiquitin-mediated degradation of FMRP and cause synaptic dysfunction | 張曉艷 | 張子超 | Hum Mol Genet | 201703 | 1 | |
4 | Neurexin Restricts Axonal Branching in Columns by Promoting Ephrin Clustering | 劉麗娜 | 韓俊海 | Dev Cell | 201704 | 1 | |
5 | Proteolytic cleavage is required for Neuroligin 2 maturation and function in Drosophila | 屠仁軍 | 謝維 | J Mol Cell Biol | 201706 | 1 | |
6 | Neurexin-Neuroligin 1 regulates synaptic morphology and functions via the WAVE regulatory complex in Drosophila neuromuscular junction | 邢廣林 | 謝維；加正平 | Elife | 201803 | 1 | |
7 | HNRNPA1-induced spliceopathy in a transgenic mouse model of myotonic dystrophy | 李默怡 | 謝維；李默怡 | Proc Natl Acad Sci U S A. 2020,117(10): 5472-5477. | 202003 | 1 | |
8 | Wnt activation protects against neomycin-induced hair cell damage in the mouse cochlea | 劉麗曼，陳巖 | 柴人杰 | Cell Death & Disease | 201603 | 2 | |
9 | Accelerating bioelectric functional development of neural stem cells by graphene coupling: Implications for neural interfacing with conductive materials | 郭榮榮 | 柴人杰；唐明亮 | Biomaterials | 201611 | 2 | |
10 | Autophagy protects auditory hair cells against neomycin-induced damage | 賀祖宏 | 柴人杰 | Autophagy | 201710 | 2 | |
11 | Critical role of spectrin in hearing development and deafness | 劉艷 | 柴人杰 | Science Advances | 201904 | 2 | |
12 | Wnt Signaling Activates TP53-Induced Glycolysis and Apoptosis Regulator and Protects Against Cisplatin-Induced Spiral Ganglion Neuron Damage in the Mouse Cochlea | 劉聞聞 | 柴人杰 | Antioxidants & Redox Signaling | 201904 | 2 | |
13 | AAV-ie enables safe and efficient gene transfer to inner ear cells | 談方志 | 柴人杰 | Nature Communications | 201908 | 2 | |
14 | A cytoskeleton structure revealed bysimaging in inner ear hair cells. | 齊潔玉 | 柴人杰 | Cell Discovery | 201909 | 2 | |
15 | Stress-Induced Metabolic Disorder in Peripheral CD4(+) T Cells Leads to Anxiety-like Behavior | 范柯琪 | 柴人杰 | Cell | 201910 | 2 | |
16 | The nuclear transcription factor FoxG1 affects the sensitivity of mimetic aging hair cells to inflammation by regulating autophagy pathways. | 賀祖宏 | 柴人杰 | Redox Biology | 202001 | 2 | |
17 | Isolation and analysis of extra cellular vesicles in a Morpho butterfly wing-integrated micro vortex biochip. | 韓善潁 | 柴人杰 | Biosensors and Bioelectronics | 202004 | 2 | |
18 | Knock-down of Foxg1 in Supporting Cells Increases the Transdifferentiation of Supporting Cells into Hair Cells in the Neonatal Mouse Cochlea. | 張莎莎 | 柴人杰 | Cellular and Molecular Life Sciences | 202004 | 2 | |
19 | Distinct roles of PKCι.λ and PKMζ in the initiation and maintenance of hippocampal long-term potentiation and memory | 王韶莉 | 陸巍 | Cell Rep | 201608 | 3 | |
20 | Learning-induced suboptimal compensation for PKCι.λ function in mutant mice | 盛濤 | 陸巍 | Cerebral Cortex | 201706 | 3 | |
21 | Genetic and neuronal mechanisms governing the sex-specific interaction between sleep and sexual behaviors in Drosophila | 陳丹丹 | 潘玉峰 | Nature communications | 201707 | 3 | |
22 | Fbxl4 Serves as a Clock Output Molecule that Regulates Sleep through Promotion of Rhythmic Degradation of the GABA(A) Receptor | 李倩 | 韓俊海 | Curr Biol | 201712 | 3 | |
23 | Drosulfakinin signaling in fruitless circuitry antagonizes P1 neurons to regulate sexual arousal in Drosophila | 吳順凡 | 潘玉峰 | Nature communications | 201910 | 3 | |
24 | Sex and Death: Identification of | 高燦 | 潘玉峰 | Neuroscience Bulletin | 202001 | 3 | |
25 | Long-Lasting Somatic Modifications of Convergent Dendritic Inputs in Hippocampal Neurons | 楊鑫 | 陸巍 | Cerebral Cortex, 2020,30: 1436–1446 | 202003 | 3 | |
26 | Enhancer, epigenetics and human diseases | 羅卓娟 | 林承棋 | Curr Opin Genet Dev | 201602 | 4 | |
27 | A permissive chromatin state regulated by ZFP281-AFF3 in controlling the imprinted Meg3 polycistron | 王艷 | 林承棋 | Nucleic Acids Res | 201702 | 4 | |
28 | Striking a balance: regulation of transposable elements by Zfp281 and Mll2 in mouse embryonic stem cells | 戴倩 | 林承棋 | Nucleic Acids Res | 201712 | 4 | |
29 | AFF3-DNA methylation interplay in maintaining mono-allelic expression of XIST in terminally differentiated cells | 張悅 | 羅卓娟 | Journal of Molecular and Cell Biology | 201909 | 4 | |
30 | ENL initiates multivalent phase separation of the super elongation complex (SEC) in controlling rapid transcriptional activation | 郭澄豪 | 林承棋 | Science Advances 2020,6(14) | 202004 | 4 | |
31 | A genome-wide association study identifies six novel risk loci for primary biliary cholangitis | 邱方 | 劉向東 | Nature Communication | 201704 | 5 | |
32 | Bidirectional regulation of fragile X mental retardation protein phosphorylation controls rhodopsin homoeostasis | 王曉 | 韓俊海 | JOURNAL OF M | 201704 | 5 | |
33 | Genome wide association studies of specific antinuclear autoantibody subphenotypes in primary biliary cholangitis | 王嬋 | 劉向東 | Hepatology | 201907 | 5 | |
34 | Fine Mapping of the MHC Region Identifies Major Independent Variants Associated With Han Chinese Primary Biliary Cholangitis | 王嬋 | 劉向東 | Journal of autoimmunity 2020,107 | 202002 | 5 | |
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