屠仁軍教授博士生導(dǎo)師
E-mail: [email protected]
辦公地點(diǎn):東南大學(xué)江北校區(qū)匯川樓B座
個人簡介:
2011年于東南大學(xué)獲得學(xué)士學(xué)位, 2017年于同校獲得博士學(xué)位。2017年至2021年在美國Stowers Institute for Medical Research從事博士后研究,隨后于2021年至2024年在香港科技大學(xué)擔(dān)任研究助理教授。2024年加入東南大學(xué)生命科學(xué)與技術(shù)學(xué)院,擔(dān)任研究員(教研系列,正高級職稱)。
研究方向:干細(xì)胞與生殖發(fā)育
干細(xì)胞具有強(qiáng)大的自我更新和分化能力,在發(fā)育和穩(wěn)態(tài)中扮演重要角色,在臨床治療領(lǐng)域亦展現(xiàn)巨大潛力。目前,對干細(xì)胞增殖、分化以及在體調(diào)控的理解仍不清晰,這給干細(xì)胞的臨床應(yīng)用帶來了許多挑戰(zhàn)。本課題組以遺傳發(fā)育領(lǐng)域經(jīng)典的模式生物果蠅為基礎(chǔ),以生殖干細(xì)胞為主要研究對象,結(jié)合哺乳動物和干細(xì)胞體外培養(yǎng),致力于研究內(nèi)源因子和微環(huán)境對成體干細(xì)胞自我更新和分化的在體調(diào)控機(jī)制。以期為干細(xì)胞與生殖發(fā)育原理、相關(guān)疾病的預(yù)防和治療,以及干細(xì)胞臨床應(yīng)用提供理論依據(jù)和試驗(yàn)基礎(chǔ)。
代表性論文:
1. Tu R#, Ping Z#, Liu J, Tsoi ML, Song X, Liu W, Xie T*. A novel dioxygenase-independent Tet function in niche-regulated stem cell maintenance. 2024, The EMBO Journal, in press.
2. Tu R#,*, Tang X#, Xu R#, Ping Z, Yu Z, Xie T*. Gap junction-transported cAMP from the niche controls stem cell progeny differentiation. PNAS, 2023, 120, e2304168120.
3. Tu R#, Duan B#, Song X, Chen S, Scott A, Hall K, Blanck J, DeGraffenreid D, Li H, Perera A, Haug J, Xie T*. Multiple niche compartments orchestrate stepwise germline stem cell progeny differentiation. Current Biology, 2021, 31, 827-839 e823.
4. Tu R, Duan B, Song X, Xie T*. Dlp-mediated Hh and Wnt signaling interdependence is critical in the niche for germline stem cell progeny differentiation. Science Advances, 2020, 6, eaaz0480.
5. Zou F#, Tu R#, Duan B#, Yang Z, Ping Z, Song X, Chen S, Price A, Li H, Scott A, Perera A, Li S*, Xie T*. Drosophila YBX1 homolog YPS promotes ovarian germ line stem cell development by preferentially recognizing 5-methylcytosine RNAs. PNAS, 2020, 117, 3603-3609.
6. Mao Y#, Tu R#, Huang Y#, Mao D, Yang Z, Lau PK, Wang J, Ni J*, Guo Y*, Xie, T*. The exocyst functions in niche cells to promote germline stem cell differentiation by directly controlling EGFR membrane trafficking. Development, 2019, 146(13).
7. Tu R, Qian J, Rui M, Tao N, Sun M, Zhuang Y, Lv H, Han J, Li M, Xie W*. Proteolytic cleavage is required for functional neuroligin 2 maturation and trafficking in Drosophila. Journal of Molecular Cell Biology, 2017, 9, 231-242.