課題組長(zhǎng)：柴人杰，東南大學(xué)生命科學(xué)與技術(shù)學(xué)院

    研究領(lǐng)域：神經(jīng)干細(xì)胞和內(nèi)耳干細(xì)胞的轉(zhuǎn)錄調(diào)控機(jī)制，聽覺神經(jīng)元和毛細(xì)胞再生

    地址：南京市玄武區(qū)四牌樓2號(hào)，東南大學(xué)李文正樓北231室，210096

    電話： 028-83790771; 18805193999

       Email： [email protected]

研究組長(zhǎng)簡(jiǎn)介：

柴人杰，1982年11月出生，東南大學(xué)生命科學(xué)與技術(shù)學(xué)院二級(jí)教授，博士生導(dǎo)師，副院長(zhǎng)；現(xiàn)任中國(guó)生物物理學(xué)會(huì)聽覺、言語(yǔ)與交流分會(huì)副會(huì)長(zhǎng)；中國(guó)生理學(xué)會(huì)干細(xì)胞與神經(jīng)分會(huì)秘書長(zhǎng)，常務(wù)理事；國(guó)際耳內(nèi)科醫(yī)師協(xié)會(huì)執(zhí)委（Executive board member）；中國(guó)聽力醫(yī)學(xué)發(fā)展基金會(huì)專家指導(dǎo)委員會(huì)常務(wù)委員，聽覺基礎(chǔ)研究專委會(huì)副主委；中國(guó)醫(yī)促會(huì)耳內(nèi)科分會(huì)聽覺基礎(chǔ)研究學(xué)組組長(zhǎng)；中國(guó)老年醫(yī)學(xué)學(xué)會(huì)耳科學(xué)分會(huì)常務(wù)委員；常務(wù)理事和生物醫(yī)藥專委會(huì)副主委，秘書長(zhǎng)；江蘇省發(fā)育生物學(xué)會(huì)常務(wù)理事，青年委員會(huì)主委和聽覺科學(xué)專委會(huì)主委；江蘇省雙創(chuàng)聯(lián)合會(huì)常務(wù)理事和生物醫(yī)藥專委會(huì)副秘書長(zhǎng)；中國(guó)研究型醫(yī)學(xué)會(huì)神經(jīng)再生與修復(fù)專委會(huì)委員；江蘇省神經(jīng)生物學(xué)會(huì)理事；美國(guó)耳鼻喉研究學(xué)會(huì)會(huì)員；國(guó)際干細(xì)胞研究學(xué)會(huì)會(huì)員，江蘇省防聾治聾技術(shù)指導(dǎo)專家組委員。先后作為課題負(fù)責(zé)人主持科技部國(guó)家重點(diǎn)研發(fā)計(jì)劃干細(xì)胞及轉(zhuǎn)化研究重點(diǎn)專項(xiàng)和科技部青年973計(jì)劃，主持多項(xiàng)國(guó)家級(jí)項(xiàng)目，國(guó)家自然科學(xué)基金委面上項(xiàng)目，人力資源和社會(huì)保障部留學(xué)人員科技活動(dòng)重點(diǎn)項(xiàng)目，教育部留學(xué)人員項(xiàng)目，全球二十強(qiáng)藥企德國(guó)Boehringer Ingelheim 公司的500萬(wàn)元的Faculty Research Award和瑞士Novartis公司70萬(wàn)元Faculty Research Award等15項(xiàng)課題。相關(guān)工作發(fā)表在Advanced Materials, Nature communications, Sciences Advances, Advanced Functional Materials,3篇PNAS，Autophagy，Biomaterials, ACS Applied Materials & Interfaces, Antioxidants & Redox Signaling, 2篇Development，Drug Delivery，Cell Death & Disease，Molecular Neurobiology等有國(guó)際影響力的學(xué)術(shù)期刊上，近5年發(fā)表SCI論文72篇（總影響因子481.8）；其中第一和通訊作者論文47篇（總影響因子292.5，其中IF>10分5篇）；作為主編出版專著人工聽覺技術(shù)概要，研究成果被國(guó)際科學(xué)網(wǎng)站和權(quán)威期刊多次正面評(píng)價(jià)和引用；另有國(guó)際會(huì)議大會(huì)發(fā)言6次，國(guó)際會(huì)議論文21篇，作為大會(huì)主席參與舉辦了三屆中國(guó)聽覺科學(xué)大會(huì)（第1,3,4屆），作為分論壇主席主持了一屆國(guó)際耳內(nèi)科醫(yī)師學(xué)會(huì)年會(huì)聽覺異常與平衡障礙分論壇（第19屆），主持了兩屆中國(guó)生物物理學(xué)會(huì)年會(huì)聽覺研究分論壇（第16,17屆），主持了一屆中國(guó)神經(jīng)科學(xué)學(xué)會(huì)年會(huì)聽覺研究分論壇（第12屆）。現(xiàn)任SCI期刊American Journal of Stem Cells(AJSC) 執(zhí)行主編 (Executive Editor-in-Chief)，American Journal of Translational Research（AJTR），Hearing Research，Frontiers of Medicine，Global Journal of Otolaryngology，Engineering和Journal of Otorhinolaryngology, Hearing and Balance Medicine（OHBM）期刊編委(Editorial Board Member)，Neural Plasticity 期刊Lead Guest Editor。

研究?jī)?nèi)容：長(zhǎng)期致力于神經(jīng)元和內(nèi)耳毛細(xì)胞的再生和保護(hù)以及神經(jīng)干細(xì)胞和內(nèi)耳干細(xì)胞的轉(zhuǎn)錄調(diào)控機(jī)制的研究。主要研究?jī)?nèi)容包括：1.系統(tǒng)的研究了多種信號(hào)通路對(duì)于內(nèi)耳干細(xì)胞和神經(jīng)干細(xì)胞增殖和分化的轉(zhuǎn)錄調(diào)控機(jī)制；2.結(jié)合多基因協(xié)同調(diào)控，生物材料和電刺激，磁刺激等物理調(diào)控因素有效促進(jìn)神經(jīng)元和毛細(xì)胞的再生和聽覺功能的部分重建；3通過調(diào)控自噬，線粒體功能和氧化應(yīng)激有效的保護(hù)了噪音和藥物導(dǎo)致的毛細(xì)胞損傷和聽力損失。

代表性論著

專著：

1. 柴人杰（主編），陳峰，陳杰，戴艷紅，高下（主編），陸玲，麻曉峰，王俊國(guó)，錢曉云，楊燁，俞晨杰，張莎莎，周函，朱光潔，人工聽覺技術(shù)概要，南京大學(xué)出版社, 352千字，ISBN 978-7-305-17890-0，2016

代表性期刊論文：

1. Yan Liu#, Jieyu Qi#, Xin Chen#, Mingliang Tang#, Cenfeng Chu, Weijie Zhu, Hui Li, Cuiping Tian, Guang Yang, Chao Zhong, Zhang Ying, Guangjian Ni, Shuijin He*, Renjie Chai*（并列通訊作者）, Guisheng Zhong*. Critical role of spectrin in hearing development and deafness. Science Advances, In Press, 2019(IF: 11.514)

2. Zhongmin Liu#, Mingliang Tang#, Jinping Zhao, Renjie Chai*（并列通訊作者）, Jiuhong Kang*. Looking into the Future: Towards Advanced Three-Dimensional Biomaterials for Stem Cell-Based Regenerative Medicine. Advanced Materials, 1705388, 2018(IF:21.950)

1. Luoran Shang, Yunru Yu, Wei Gao, Yuetong Wang, Liangliang Qu, Ze Zhao, Renjie Chai*（并列通訊作者）, Yuanjin Zhao*. Bio-inspired Anisotropic Wettability Surface from Dynamic Ferrofluid Assembled Templates. Advanced Functional Materials, 1705802, 2018(IF:13.325)

2. Sana Shaikh, Fawad Rehman, Tianyu Du, Hui Jiang, Lihong Yin, Xuemei Wang*, Renjie Chai*（并列通訊作者）. Real-time Multimodal Bioimaging of Cancer Cells and Exosomes through Biosynthesized Iridium and Iron Nanoclusters.ACS Applied Materials & Interfaces, doi: 10.1021/acsami.8b08975, 2018 (IF:8.097) 

3. Wenwen Liu, Xiaochen Xu, Zhaomin Fan, Gaoying Sun, Yuechen Han, Daogong Zhang, Lei Xu, Mingming Wang, Xue Wang, Shasha Zhang, Mingliang Tang, Jianfeng Li, Renjie Chai*（并列通訊作者）, Haibo Wang*.Wnt signaling activates TIGAR and protects against cisplatin-induced spiral ganglion neuron damage in the mouse cochlea.Antioxidants & Redox Signaling, doi: 10.1089/ars.2017.7288, 2018 (IF:6.530)

4. Wenqing Yan#, Wenwen Liu#, Jieyu Qi, Qiaojun Fang, Zhaomin Fan, Gaoying Sun, Yuechen Han, Daogong Zhang, Lei Xu, Mingming Wang, Jianfeng Li, Fangyi Chen, Dong Liu*, Renjie Chai*（并列通訊作者）, Haibo Wang*. A Three-Dimensional Culture System with Matrigel Promotes Purified Spiral Ganglion Neuron Survival and Function In Vitro.Molecular Neurobiology, 55(3):2070-2084., 2018(IF:6.19)

5. Zuhong He#, Lingna Guo#, Yilai Shu#, Qiaojun Fang, Han Zhou, Yongze Liu, Dingding Liu, Ling Lu, Xiaoli Zhang, Xiaoqiong Ding, Dong Liu, Mingliang Tang, Weijia Kong, Suhua Sha, Huawei Li*, Xia Gao*, Renjie Chai*（并列通訊作者）. Autophagy protects auditory hair cells against neomycin-induced damage. Autophagy, 2:1-21, 2017(IF:11.100)

6. Shasha Zhang, Yuan Zhang, Pengfei Yu, Yao Hu, Han Zhou, Lingna Guo, Xiaochen Xu, Xiaocheng Zhu, Muhammad Waqas, Jieyu Qi, Xiaoli Zhang, Xiaoyun Qian, Fangyi Chen, Mingliang Tang, Yan Liu, Haibo Shi*, Xia Gao*, Renjie Chai*（并列通訊作者）. Characterization of Lgr5+ progenitor cell transcriptomes after neomycin injury in the neonatal mouse cochleae.Frontiers in Molecular Neuroscience, 10:213, 2017(IF:5.076)

7. Xiaoling Lu#, Shan Sun#, Jieyu Qi, Wenyan Li, Liman Liu, Yanping Zhang, Yan Chen, Shasha Zhang, Lei Wang, Dengshun Miao, Renjie Chai*（并列通訊作者）, Huawei Li*. Bmi1 regulates the proliferation of cochlear supporting cells via the canonical Wnt signaling pathway. Molecular Neurobiology, 54(2):1326-1339, 2017(IF:6.19)

8. Rongrong Guo#, Shasha Zhang#, Miao Xiao, Fuping Qian, Zuhong He, Dan Li, Xiaoli Zhang,  Huawei Li, Xiaowei Yang, Ming Wang, Renjie Chai*（并列通訊作者）, Mingliang Tang*.Accelerating bioelectric functional development of neural stem cells by graphene coupling: Implications for neural interfacing with conductive materials. Biomaterials, 106:193-204. 2016(IF:8.402)

9. Liman Liu#, Yan Chen#, Jieyu Qi Yanping Zhang, Yingzi He, Wenli Ni, Wen Li, Shasha Zhang, Shan Sun, Makoto Taketo, Lei Wang, Renjie Chai*（并列通訊作者）, Huawei Li*. Wnt activation protects against neomycin-induced hair cell damage in the mouse cochlea.Cell Death & Disease, 10;7:e2136, 2016(IF:5.965)

10. Tian Wang#, Renjie Chai#（并列第一作者）, Grace Kim, Nicole Pham, Lina Jansson, Duc-Huy Nguyen, Bryan Kuo, Lindsey May, Jian Zuo, Lisa Cunningham, Alan Cheng*. Lgr5+ cells regenerate hair cells via proliferation and direct transdifferentiation in damaged neonatalmouse utricle. Nature Communications, 7;6:6613, 2015(IF:11.47)

11. Brandon Cox#, Renjie Chai#（并列第一作者）, Anne Lenoir, Zhiyong Liu, LingLi Zhang, Duc-Huy Nguyen,Kavita Chalasani, Katherine Steigelman Jie Fang, Alan Cheng*, Jian Zuo*. Spontaneous hair cell regeneration in the neonatal mouse cochlea in vivo.Development, 141,816-29, 2014(IF:6.462)

12. Taha Jan#, Renjie Chai#（并列第一作者）, Zahra Sayyid, Renée Amerongen, Anping Xia, Tian Wang,Saku Sinkkonen, Yi Zeng, Jared Levin, Stefan Heller, Roel Nusse*, Alan Cheng*.  Tympanic border cells are Wnt-responsive and act as progenitors for postnatal mouse cochlear cells. Development,140, 1196-1206, 2013(IF:6.273)

13. Renjie Chai#, Bryan Kuo#, Tian Wang, Eric Liaw, Anping Xia, Taha Jana, Zhiyong Liu, Makoto M. Taketo, John Oghalai, Roeland Nusse, Jian Zuo*, Alan Cheng*. Wnt signaling induces proliferation of sensory precursors in the postnatal mouse cochlea. Proc Natl Acad Sci U S A, 109(21):8167-72, 2012 (IF:9.737)